Real Life can be much more interesting than fiction. With over 500 episodes, The Simpsons have used a lot of ideas. So many reality is starting to copy them...
A parody on The Simpsons of Siegfried & Roy ends in a tiger attack, ten years before a real incident.
16 December 1993: The Simpsons episode "$pringfield (Or How I Learned to Stop Worrying and Love Legalized Gambling" first aired. In it C. Montgomery Burns opens a casino in Springfield and hires flamboyant magicians Gunter & Ernest, an obvious parody of real-life Vega magic act Siegfried & Roy. In the episode, Antastasia, the white tiger in the act attack the duo. Hilarity ensues.
03 October 2003: During a performance of Siegfried & Roy's ongoing show at the Mirage Casino, the white tiger Mantecore attacked Roy, latching onto his neck, putting him in hospital where he coded 3 times and needed 25% of his skull removed. In 2013, he remained "a little bit handicapped" by the incident. Mantecore died in 2014 after a short illness.
Obviously, with an animal act, there is always a danger, even/especially after so many years was always a possibility (although not guaranteed), however the coincidence remains. Whether the joke on The Simpsons is now no longer funny - or is even funnier - is left up to the reader.